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pentobarbital will decrease the level or effect of isavuconazonium sulfate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.Contraindicated (1)pentobarbital will reduce the extent or impact of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or outcome of guanfacine b